We are seeking a self-motivated researcher who is excited to join a dynamic and collaborative team of scientists driving the discovery of novel small molecule therapeutics in genetic diseases.
In this role, you will design and execute molecular and cell biology experiments focused on evaluation of candidate molecules, and development of novel biomarkers. You will interact and collaborate cross-functionally with scientists in other departments, including biochemists, chemists, and computational and structural biologists while growing your understanding of drug discovery and helping bring medicines to patients.
- Design and perform cell and molecular biology experiments to support the biological evaluation of small molecules impacting genetic disease targets
- Transfect/transduce mammalian cell lines with various disease-relevant mutant constructs
- Develop, optimize and conduct cell-based assays to enable medicinal chemistry efforts and structure activity relationship assessment
- Develop and perform target engagement assays from patient-derived cells and/or in vivo samples
- Maintain good written records of laboratory procedures, results and conclusions
- Analyze data carefully and report findings to the team
- Collaborate with CROs for any outsourcing needs and integrate data analysis
- Present your work at regular department and company meetings
- MS/BS, 0 – 4 years of industry/academic experience working in the genetic disease space is desirable
- Adept at nucleic acid purification, DNA cloning, PCR, gel electrophoresis, Western blotting, qPCR, si/shRNA, CRISPR, lentiviral gene knockdown
- Exceptional cell biology capabilities (experience with patient-derived cells, iPSC differentiation, flow cytometry, microscopy, familiarity with cellular assays employing luminescence and fluorescence readouts).
- Ability to design and execute experiments, analyze and document results
- Excellent organizational and communication skills
- Excellent problem-solving skills and ability to multi-task